The main function of major histocompatibility complex (MHC) class II molecules is to present processed antigens, which are derived primarily from exogenous sources, to CD4(+) T-lymphocytes. MHC class II molecules thereby are critical for the initiation of the antigen-specific immune response. Besides antigen presentation, growing evidence is showing that ligation of MHC class II molecules also activates intracellular signaling pathways.
Chloroquine is known to inhibit major histocompatibility complex (MHC) class II presentation of antigen in vitro by affecting invariant chain dissociation from MHC class II.
MHC class II proteins specialize in presentation of exogenous antigens to TCR of CD4+ T-cells.
MHC class II molecules are assembled in the endoplasmic reticulum by the chaperone CD74, which directs these complexes to the endosomal compartments
So if the chloroquine increases the ph of endosomes it will affect the MHC class II antigen presentation ability
Graft-versus-host disease (GVHD) caused by T-cell recognition of minor histocompatibility (MiHC) antigens is a major complication of bone marrow transplantation. GVHD therapy has focused on removal or suppression of donor T cells, but modulation of MiHC antigen presentation to CD4+ T cells may represent an alternative approach.So providing chloroquine can increase the compatibility of the graft
Chloroquine is known to inhibit major histocompatibility complex (MHC) class II presentation of antigen in vitro by affecting invariant chain dissociation from MHC class II.
MHC class II proteins specialize in presentation of exogenous antigens to TCR of CD4+ T-cells.
MHC class II molecules are assembled in the endoplasmic reticulum by the chaperone CD74, which directs these complexes to the endosomal compartments
So if the chloroquine increases the ph of endosomes it will affect the MHC class II antigen presentation ability
Graft-versus-host disease (GVHD) caused by T-cell recognition of minor histocompatibility (MiHC) antigens is a major complication of bone marrow transplantation. GVHD therapy has focused on removal or suppression of donor T cells, but modulation of MiHC antigen presentation to CD4+ T cells may represent an alternative approach.So providing chloroquine can increase the compatibility of the graft
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| Membrane transport through endosomal compartments can be perturbed by agents that interfere with endosome acidification, such as membrane-permeant weak bases like chloroquine |
