Describe this region and the factors it makes. In what way could we say that it resembles Spemann's organizer? what phenotype results when at least 1 of these factors is eliminated by generating homozygous kockout mice?

The sequence of events ---- Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest

A region of the brain can give rise to an entire cerebellum when transplanted from the midbrain/hindbrain region to the anterior forebrain.

Neural development is one of the earliest systems to begin and the last to be completed after birth.

Neurulation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system

Isthmus organizer metencephalon so the Isthmus organizer is the speiman organizer

Lmx1b ,Wnt1,Fgf8,domains of the homeobox genes Otx-2 and Gbx-2

The phenotype which might arise

The early central nervous system begins as a simple neural plate that folds to form a groove then tube, open initially at each end. Failure of these opening to close contributes a major class of neural abnormalities neural tube defects.Such as spina bifida

Development of nervous system